抗原免疫原及其识别概念.ppt

抗原识别的重要性及意义 TCR 抗原肽 MHC-II T 细胞 APC细胞 MHC分子与抗原肽的相互作用 “识 别” 才 是 硬 道 理! Antibody TCR MHC HIV peptide How is the pathogen recognized? 感谢上帝赐予免疫系统！ School of Medicine Fudan University * * Costimulation Sig2 (co-stimulation) 1975 Lafferty Cunningham T helper cells die when they see antigen unless rescued by co-stimulation(signal two) from APCs. bacterium PRRs 1989 Janeway APCs do not co-stimulate unless activated via PRRs(receptors for evolutionarily distant infectious non-self) PRRs-PAMPs C. A. Janeway, Jr., M.D. The Infectious-Nonself Model (1943-2003 ) APCs are activated b