肾病患儿中药治疗前后超氧化物歧化酶的变化.docVIP

肾病患儿中药治疗前后超氧化物歧化酶的变化 【摘要】 目的观察益肾活血中药对肾病的疗效。方法68例肾病患儿随机分为治疗组与对照组各34例，治疗组在对照组治疗基础上加用益肾活血药。测定治疗前后超氧化物歧化酶（SOD）及血清过氧化脂质（LPO）含量的变化，分别与30名健康儿童作比较。结果肾病患儿SOD明显低于健康儿童组（P＜0.01)，而LPO明显高于健康儿童组（P＜0.01)。治疗4周后治疗组SOD水平明显升高（P＜0.01)，LPO明显下降，与对照组相比有显著性差异（P＜0.01)。结论 益肾活血药对抗过氧化损伤、防治肾病有一定临床意义。 【关键词】 肾病； 益肾活血药； 超氧化物歧化酶 　　Changes in Blood Superoxide Dismutase before and after Treatment of Chinese Drugs in Patients with Nephrosis 　　Abstract：ObjectiveTo observe the curative effect of chinese drugs for reinforcing the kidney and promoting blood circulation on nephrosis.MethodsSixty-eight cases of nephrosis were divided into treatment group and control group, the reinforcing the kidney and promoting blood circulation was applied to treatment group on the base of control group treatment.Then changes of serum superoxide dismutase (SOD) and lipid perixidatio (LPO) were compared between the two groups.ResultsThe serum SOD level in nephrosis patients was lower than that in healthy children （P＜0.01),but the serum levels of LPO were higher in nephrosis patients than in healthy children （P＜0.01). After four-week treatment, the serum level of SOD increased obviously（P＜0.01). The serum levels of LPO decreased obviously in treatment group. There were significant difference between the two group（P＜0.01). ConclusionChinese drugs forreinforcing the kidney and promoting blood circulation can increase the activity of SOD to antagonice peroxide-induced damage, and therefore can treat the weakness of kidney. 　　Key words：Nephrosis; Reinforcing the kidney and promting blood circulation; Superoxide dismutase 　　肾病是由各种病因引起的肾小球毛细血管通透性增高导致大量蛋白尿的临床症候群。其病因未明，详细的发病机制尚不清楚。在多发病因素中脂质过氧化因素尤为重要，氧自由基参与肾病病理损伤过程［1］。我们采用益肾活血中药治疗单纯性肾病，并以超氧化物歧化酶（SOD）、过氧化脂质（LPO）作为判断疗效的治疗指标。现报道如下。 　　1 资料与方法 　　1.1 临床资料选自住院后确诊为单纯性肾病患儿68例,均符合单纯性肾病诊断标准［2］。随机分为治疗组与对照组。治疗组34例,其中男24例，女10例，平均年龄（6±3.2)岁；对照组34例,其中男22例，女12例，平均年龄（6±3.4）岁。两组病例在性别、年龄、病情等方面比较均无显著差异（P＞0.05),具有可比性。另选择30例健康儿童（某幼儿园儿童）作比较。 　　1.2 治疗方法两组患者均