胃康平煎剂治疗肝郁脾虚型功能性消化不良临床研究.docVIP

胃康平煎剂治疗肝郁脾虚型功能性消化不良临床研究 作者：刘建平 赵红伟 代叶红 陈建权 郎晓猛 【摘要】 目的 观察胃康平煎剂治疗肝郁脾虚型功能性消化不良的临床疗效。方法 将80例肝郁脾虚型功能性消化不良患者随机分为2组。治疗组40例予胃康平煎剂，每日1剂，水煎取汁300 mL，分早晚饭前30 min各服150 mL。对照组40例予吗丁啉，每次10 mg，每日3次口服。2组均2周为1个疗程，1个疗程后统计疗效，并测定2组治疗后血清一氧化氮（NO）及血浆乙酰胆碱酯酶（AchE）和胃动素（MTL）的含量。结果 治疗组总有效率90%，对照组总有效率65%，2组比较差异有统计学意义（Plt;0.01）；治疗后治疗组血清中NO含量明显降低，与对照组比较差异有统计学意义（Plt;0.05），血浆中AchE、MTL含量明显升高，与对照组比较差异有统计学意义（Plt;0.05）。结论 胃康平煎剂治疗肝郁脾虚型功能性消化不良疗效确切，其机制可能与降低血清中NO含量，增强血浆中AchE、MTL的含量及促进胃排空有关。 【关键词】 汤剂； 消化不良；中药疗法 　　Clinical research on the therapeutic effect of Weikangping decoction on 40 cases of functional dyspepsia 　　【Abstract】 Objective To observe the clinical effect of Wei kangping decoction on Functional Dyspepsia （FD） of liver depression and spleen a sthenia. Methods 80 FD patients were randomly divided into 2 groups.40 cases in treatment group were given one dose of 150 mL each time, twice a day, 30 minutes before breakfast and supper; other 40 cases in control group, were given Domperidone 10 mg each time, 3 times a day. The treatment course for both groups was 2 weeks. Results The total effective rate was 90% in treatment group, which is 65% in control group, there was a significant difference between two groups （Plt;0.01）; After the treatment, serum NO content was obviously lower in treatment group （Plt;0.05）; blood plasma AchE and MTL content obviously ascended in treatment group after the treatment （Plt;0.0 5）. Conclusion Weikangping decoction has precise therapeutic effect on Functional Dyspepsia of liver depression and spleen asthenia. The me chanism may be concerned with lowering serum NO content, ascending blood plasma AchE and MTL content and promoting gastric emptying. 　　【Key words】 Decoction; Dyspepsia; TCM therapy 　　功能性消化不良（functional dyspepsia，FD）是消化科常见病、多发病，临床主要表现为持续性或反复发作性上腹不适、腹部胀气、餐后饱胀、嗳气、早饱、厌食、恶心、呕吐、烧心等消化功能障碍症状。据西方国家报道，FD占消化专科门诊的14%～32%，国内FD在社会人群中患病率在10%～30%，占消化门诊人数的40%左右［1］。2005-07—2006-07，我们采用胃康平煎剂治疗肝郁脾虚型功能性消化不良40例，并与吗丁啉治疗40例对照观察