MB-5-repair-08开题报告.ppt

Damage Caused by Alkylation of Bases Alkylating agents like ethylmethane sulfonate (EMS) add alkyl groups to bases Some alkylation don’t change base-pairing, innocuous Others cause DNA replication to stall Cytotoxic Lead to mutations if cell attempts to replicate without damage repair Third type change base-pairing properties of a base, so are mutagenic 4) Damage Caused by Radiation Ultraviolet rays Comparatively low energy Cause a moderate type of damage Result in formation of pyrimidine dimers Gamma and x-rays Much more energetic Ionize molecules around the DNA Form highly reactive free ra