18F-FDGPETCT影像辅助CT引导下经皮组织学穿刺活检术的初步临床应用..docVIP

18F-FDG PET/CT影像辅助CT引导下经皮组织学穿刺活检 孙龙，官泳松，方亚，潘卫民，陈贵兵，罗作明，魏继宏，吴华 CT Guided Tissue Core Biopsy Modulated With 18F-FDG PET/CT Image: Initial Clinical Results Long Sun, Wei-Ming Pan, Gui-Bing Chen, Zuo-Ming Luo, Ji-Hong Wei, Hua Wu, Minnan PET Center, The First Hospital of Xiamen, Fujian Medical University, Xiamen 316003, China. Yong-Song Guan, West China Hospital of Sichuan University, Chengdu, China, 610041；Ya Fang, Statistics， Medical college, Xiamen University, Xiamen 361000, China Correspondence author: Hua Wu, Email: wuhua1025@163.com ＿＿＿＿＿＿＿＿＿＿＿ 作者单位：福建医科大学附属厦门第一医院核医学、闽南PET中心孙龙，潘民，魏继宏，吴华。 四川大学华西医院官泳松。厦门大学医学院方亚目的 评价一日法FDG PET/CT全身扫描联合18F-FDG PET/CT影像辅助CT引导下经皮组织学穿刺活检术应用于恶性实体肿瘤分期与定性诊断的临床价值。方法 连续16例病变，全身FDG PET/CT扫描结合18F-FDG PET/CT影像辅助CT引导下经皮组织学穿刺活检。每例患者FDG PET/CT全身18F-FDG PET/CT影像辅助CT引导下经皮组织学穿刺活检均日在同一PET/CT扫描仪上完成。结果FDG PET/CT影像诊断与穿刺活检组织学病理结果一致。10例18F-FDG PET/CT诊断为恶性者，最终诊断为恶性8例 (8/10，80％)，良性2例 (2/10例，20％)。6例18F-FDG PET/CT诊断为良性者，最终诊断为良性2例 (2/6，44％)，恶性4例(4/6例，66％)。穿刺活检结果与最后手术病理和随访诊断全部符合。PET/CT影像诊断与穿刺活检结果之间，两种方法统计学分析无差异(P=0.604)。所有最后诊断为恶性实体性肿瘤的患者，定性与分期在一日内完成；诊断为良性者则规定门诊长期随访，排除假阴性。穿刺获取组织学标本时间为每例15分钟。本组病例均无严重并发症发生。结论 全身FDG PET/CT扫描联合18F-FDG PET/CT影像辅助CT引导下经皮组织学穿刺活检 【关键词Abstract】 Objective In many cases18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (18F-FDG PET/CT) can not give differentiation between benign and malignant lesions. Any positive finding that could lead to a clinically significant change in patient management should be confirmed by subsequent histopathologic examination because of the risk of false-positive results. This study was carried out to evaluate the value of 18F-FDG FDG PET/CT in combination with CT guided tissue core biopsy modulated with 18F-FDG PET/CT image on a same day in the patients with mass lesions. Methods Sixteen consecutive patients with detectable lesions underwent CT guided tissue core biopsy modulated with 18F-FDG PET/CT image after whole body 18F-FDG PET/CT scan. Both PET/CT scan and biopsy pro