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ESC in developmental biology to study the role of specific genes in development; to isolate early-stage populations; to identify progenitors that represent novel stages of hematopoietic, vascular, and neural development; to define the factors that regulate primary germ layer induction. Human stem cells as a model for cardiac differentiation and disease Hematopoietic stem cell development is dependent on blood flow. Cell. 2009 May 15;137(4):736-48. During vertebrate embryogenesis, hematopoietic stem cells (HSCs) arise in the aorta-gonads-mesonephros (AGM) region. We report here that blood
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