比卡鲁胺联合戈舍瑞林间歇性治疗局部晚期前列腺癌的临床观察及护理要点总结.doc

比卡鲁胺联合戈舍瑞林间歇性治疗局部晚期前列腺癌的临床观察及护理要点总结 曲静坤 中国医科大学附属第一医院泌尿外科 110000 【摘要】目的：观察比卡鲁胺联合戈舍瑞林间断性治疗对局部晚期前列腺癌的疗效，探讨局部晚期前列腺癌患者的护理要点。方法：随机将本院2005年7月－2012年7月收治的前列腺癌晚期患者146例分为对照组及观察组，各73例。对照组给予比卡鲁胺（口服50mg/次，qd）并联合戈舍瑞林（注射3.6mg/次，1次/4周）持续治疗；观察组予比卡鲁胺联合戈舍瑞林间断治疗，两组均配合相同护理措施。分别观察并记录两组患者在治疗前、治疗后1、6、12个月时的血清PSA、f－PSA的变化，排尿梗阻症状及骨转移灶改善情况。统计两组治疗费用，并记录治疗期间不良反应发生的情况。结果：与治疗前相比，两组情况均有明显改善，肿瘤标志物血清PSA及f-PSA值均显著下降，有自觉排尿梗阻症状及骨转移灶患者人数显著减少，差异均具有统计学意义（P 0.05），但组间不具有统计学意义（P＞0.05）。观察组平均治疗费用明显低于对照组，组间具有统计学意义（P 0.05）。两组发生的主要不良反应为性功能障碍、潮热等。观察组主要不良反应发生率远低于对照组，具有统计学意义（P＜0.05）。结论：综上所述，应用比卡鲁胺联合戈舍瑞林间歇性治疗局部晚期前列腺癌的疗效与持续性治疗相同，同时配合护理措施更能有效缓解患者临床症状。但间歇性治疗可显著减少患者的的医疗费用，且不良反应少，安全性更高，值得在临床推广。 【关键词】比卡鲁胺 戈舍瑞林 前列腺癌 临床观察 护理要点 Observe the clinical?efficacy of Bicalutamide combined with Goserelin to treat locally advanced prostate cancer and summary the nursing points [Abstract] Objective：To observe the efficacy of Bicalutamide combined with Goserelin for locally advanced prostate cancer; Summary the care points. Methods：Controlled trials using grouping method, randomly Court in July 2005 - with advanced prostate cancer in July 2012 admitted 146 cases into two groups, 73 cases continued medical castration group and 73 cases of intermittent medical castration group. Continuing medical castration group was given bicalutamide combined with goserelin, intermittent medical castration group administered with continuous medical castration group, when serum PSA value decreased to stop patients administered 0.2ng / ml or less, PSA value re-raised 4ng / ml or more, and then drug treatment. Two groups of patients were observed and recorded before treatment, after treatment, serum PSA 1,6,12 months time, f-PSA changes in urination obstructive symptoms, the number of patients with bone metastases, as well as medical costs and adverse reactions and Compare, thereby evaluating bicalutamide joint goserelin intermittent treatment of locally advanced prostate cancer effects, and summarize nursing points. Results：The two groups of pa