第六讲NMR介绍.ppt

*/43 NMR spectroscopy of protein in living cells (In-cell NMR) Sakakibara et al, Nature, 2009 */43 Inomata et al, Nature, 2009 NMR structure of protein in living cells (In-cell NMR) */43 Fraser syndrome is a recessive multisystem disorder characterized by embryonic epidermal blistering, cryptophthalmos, syndactyly, renal defects Takamiya et al, Nat genet. 2004 PDZ7 PDZ6 PDZ5 PDZ1 PDZ2 PDZ3 PDZ4 L1 L2(KBD) Fras1 Combination of NMR and X-ray techniques in structural biology */43 Folding research of GRIP1-PDZ12 by NMR and CD spectroscopy */43 PDZ12/Fras1 复合物晶体 晶体衍射图 PDZ12/Fras1 复合物的晶体结构 Long