FoxM1剪接异构体在上皮性卵巢癌中的表达及相关功能研究.docVIP

FoxM1剪接异构体在上皮性卵巢癌中的表达及临床意义研究 [摘要] 目的：观察FoxM1剪接异构体在上皮性癌的表达特征探讨其价值性组经治疗及术中获取病灶组织病理检测确诊的上皮性卵巢癌者性组学及病理诊断为良性肿瘤组其它妇科疾病入院但经临床症状学检查等未见卵巢异常者取卵巢病理组织切片组化色光法检测oxM1表达阳性情况恶性和健康组卵巢组织oxM1的表性率比较差异具有统计学意义2=62.632，P0.01），两两比较性组显著高于良性组及健康组2=27.473，60.864，P0.01），良性组显著高于组2=10.187，P0.01）。不同临床分期上皮性卵巢癌本oxM1的表达具有显著性I期病变oxM1阳性率显著低于II、IV期（X2=5.882，P0.05）。但浆液性乳头状囊腺癌oxM1阳性率非浆液性乳头状囊腺癌无显著性2=0.039，P0.01）。恶性肿瘤患者随着FoxM1表达增强，患者的3年生存率（OS）和无进展生存率（PFS）逐渐下降。结论：FoxM1剪接异构体在上皮性卵巢癌中为高表达着临床分期的增oxM1的阳性率提高oxM1表达增高恶性肿瘤患者的生存率下降，FoxM1可能参与癌的发生与展过程机制可能与oxM1的细胞周期调控作用有关oxM1剪接异构体，上皮性卵巢癌，基因表达，细胞周期The expression and clinical significance study of FoxM1 isoforms in epithelial ovarian cancer [Abstract] Objective: To observe expression features of FoxM1 isoform in women with epithelial ovarian cancer, and to explore its value. Methods: 50 cases of malignant group, were the patients treated by surgery and got intraoperative detection of pathological lesions diagnosed epithelial ovarian cancer; 50 cases of benign group, were patients of diagnostic imaging and pathological ovarian benign tumor; 50 cases of healthy group, were patients admission but for other gynecological diseases by clinical symptoms, imaging studies, such as no ovarian abnormalities. Ovarian pathology tissue sections were taken immunohistochemistry, FoxM1 expression positive situation was detected by immunofluorescence. Results: The difference of FoxM1 ovarian tissue expression rate of malignant, benign and healthy group was statistically significant (X2= 62.632, P 0.01), pairwise comparison, the malignant group was significantly higher than that of benign group and the healthy group (X2=27.473, 60.864, P0.01), the benign group was significantly higher than the healthy group (X2 = 10.187, P0.01). The difference of expression in epithelial ovarian cancer samples FoxM1 of different clinical stages was significant, the FoxM1 positive rate of I, II lesionswas significantly lower than the III, IV stage (X2=5.882, P0.05). But the difference of FoxM1 positive rate