生物可吸收支架现状与展望北京安贞医院程姝娟.ppt

restoration of physiological vasomotion, mechanotransduction, adaptive shear stress, late luminal gain (as opposed to late luminal loss with permanent stents), and late expansive remodelling.22 The absence of any residual foreign material and restoration of functional endothelial coverage can also reduce the risk of stent thrombosis and need for long-term dual antiplatelet therapy (DAPT). Additionally, BRS can overcome some other problems associated with use of the permanent metallic stents such as ‘jailing’ of the side branches, overhang at ostial lesions, and inability to graft the stented segment * * due to the lack of an ideal polymer at that stage (low-molecular-weight polylactides were associated with an intense inflammatory neointimal response。IGAKI-TAMAIw failed to become a mainstream player due to concerns about use of the heated contrast in coronary arteries, although the device has a Conformite ′ Europe′enne (CE) mark for use in peripheral arteries。 * * 聚乳酸-羟基乙酸共聚物 * * Middle, Sequential changes in strain assessed by IVUS palpography. Prestenting shows a long area of high strain (color coded for strain ranging from 1% to 2%); on a single cross section, the high-strain region is located at the shoulder (7 to 8 o’clock) of the plaque.After scaffolding, abolition of this high strain spot is documented. At 6 months and 2 years after scaffolding, high strain remained absent. Bottom, IVUS virtual histology (IVUS-VH) images after the procedure and at 6 and 24 months after implantation of BVS 1.0, respectively. With IVUS-VH, the struts were misclassified as dense calcium after the procedure and at 6 months, whereas at 24 months, they were no longer visible.高张力。纤维斑块定义为深绿色区域，主要由胶原纤维构成；纤维脂肪斑块定义为浅绿色区域，主要由包含脂质的松散胶原纤维构成，其中没有坏死组织的成份；坏死核心组织定义为红色区域，主要是由大量的死亡细胞和脂质所构成；钙化定义为白色区域，这种组织是由大量钙盐晶体沉积而成。 * * deze biodegradeerbare stent kan stabiliseren een inflammatoire plaque. Op de animatie zien we een plaque groeien met het optreden van een dunne cap – met tenslotte het scheuren