Experimental Procedures for Sensitive and Reproducible In Situ原位敏感和重现性的实验程序.pptxVIP

下载本文档

2
0
约1.39万字
约 20页
2017-06-15 发布于上海
举报
版权申诉

Experimental Procedures for Sensitive and Reproducible In Situ原位敏感和重现性的实验程序.pptx

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Direct and Repeated Clinical Measurement of pO2 for Enhancing Cancer Therapy 2014 Norris Cotton Cancer Center Comprehensive Thoracic Oncology Program (CTOP) Retreat Benjamin B. Williams, Ph.D. The Geisel School of Medicine at Dartmouth, Departments of Medicine (Radiation Oncology) and Radiology May 22, 2014 Clinical EPR at Dartmouth Clinical problem Parameter to be measured Status of measurements in human subjects Rationale for using in vivo EPR Cancer pO2 in tumors Numerous measurements performed in patients with superficial tumors. FDA IDE submitted for application of implantable oxygen sensors for application at increased depth and with increased sensitivity NCI PPG proposal in review Established collaborations with external academic institutions The response of tumors to cytotoxic therapy, especially ionizing radiation, is critically dependent on pO2. Anti-tumor therapies are given repeatedly and often change pO2. Knowledge of the changes in individual patients would significantly optimize the timing of the therapy Potential exposure to clinically significant doses of radiation Radiation-induced EPR signals in teeth (magnitude is proportional to dose) Underway in unirradiated volunteers and patients receiving significant doses to teeth from radiation therapy. Measurements at remote locations possible using transportable device. Established collaborations with external academic institutions Exposures may occur from terrorism, war, or accident. In vivo EPR is the only physical method capable of making measurements ‘after-the-fact Peripheral vascular disease Oxygen at sites of likely pathologies Measurements underway in normal volunteers. The pO2 in the tissues is the most significant pathophysiological variable; no other method available to make such direct measurements. Radiation Induced Fibrosis pO2 in irradiated tumor beds and peripheral normal tissue Recruitment and measurements underway Radiation-induced hypoxia may play a critical role in the signaling