静电纺丝论文生物相容性纳米复合材料的制备与应用.docVIP

静电纺丝论文：生物相容性纳米复合材料的制备与应用 【中文摘要】21世纪,生物医用材料越来越成为世界各国的研究热点。生物相容性是生物医用材料区别于任何其他材料的最主要特征,是评价一种材料能否在生物医学领域应用的根本依据。本论文中,我们研究的对象为壳聚糖(Chitosan,CS)、聚乙烯吡咯烷酮(Polyvinylpyrrolidone,PVP)以及氢氧化钙,它们均具有良好的生物相容性。近年来,利用静电纺丝制备的纳米纤维及纳米纤维毡已经成为生物医学领域的研究热点。电纺纳米纤维及纤维毡具有的高性能和多功能性使得它们广泛应用于生物医学领域,例如组织工程、生物传感器、创敷材料、药物载体和酶的固定等方面。PVP和CS都以具有良好的生物相容性而出名,特别地,CS具有抗菌能力,PVP具有止血作用。因此,本文中,我们运用静电纺丝技术制备了CS/PVP双功能纳米复合纤维,并使用扫描电镜、透射电镜、红外光谱仪、X射线衍射仪对其进行了表征,同时利用热分析仪研究了纳米复合纤维毡的热稳定性。通过对实验结果的分析,我们认为制备的CS/PVP双功能纳米复合纤维是一种优秀的生物医用材料,能广泛应用于创伤敷料、生物支架、组织工程等生物医学领域。另外,由于普通氢氧化钙类根管充填材料具有封闭性差、抑菌作用较弱等缺点。我们采用滴定沉淀法合成纳米氢氧化钙,为纳米氢氧化钙根管充填材料的制备提供良好的基础。 【英文摘要】In the 21st century, the research of biomedical materials more and more becomes hot spots around the world. Biomedical materials are different from any other materials due to its biocompatibility, and the biocompatibility is the basis to evaluate whether a material in biomedical application. In this paper, Chitosan (CS), Polyvinylpyrrolidone (PVP) and calcium hydroxide all have excellent biocompatibility.Recently, the electrospun nanofibrous mats have become a very hot research topic in the area of biomedical materials. Above of all, electrospinning is a progressive and efficient method for manufacturing high performance nan?obers and mats due to its versatility and potential for applications in diverse fields. The notable applications include in tissue engineering, biosensors, filtration, wound dressings, drug delivery, and enzyme immobilization. Both PVP and CS were well known for their biocompatible and biodegradable properties, especially, CS has antibacterial property, PVP has hemostatic effect. In our present work, a series of CS/PVP dual-function blend nanofibers and mats were fabricated with different weight ratio of CS to PVP by electrospinning method. The diameter, morphology, structure, and properties of nanofibers and mats were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrare