他克莫司软膏联合CO2点阵激光治疗苔癣样皮肤淀粉样变疗效观察.docVIP

他克莫司软膏联合CO2点阵激光治疗苔癣样皮肤淀粉样变疗效观察 　　[摘要]目的：探讨0.1%他克莫司软膏联合CO2点阵激光治疗苔癣样皮肤淀粉样变的疗效及安全性。方法：治疗组32例，给予CO2点阵激光治疗苔癣样皮肤淀粉样变治疗1次，痂皮脱落后予1%他克莫司软膏外抹，1周2次，共4周；对照组31例,予单独外用0.1%他克莫司软膏，2次/天，共4周。结果：治疗组有效率为78.12%，对照组有效率为41.94%，治疗组复发率为24.00%,对照组复发率为53.8%， 两组差异具有统计学意义，治疗组好于对照组，治疗组复发率低于对照组。结论：0.1%他克莫司软膏联合CO2点阵激光治疗苔癣样皮肤淀粉样变疗效安全、有效，复发率相对较低，患者依从性较高。 　　[关键词]0.1%他克莫司软膏;CO2点阵激光;苔癣样皮肤淀粉样变 　　[中图分类号]RR730.57[文献标识码]A [文章编号]1008-6455（2014）05-0386-03 　　 　　 Clinical efficacy of tacrolimus ointment with lattice CO2 laserin the treatment of lichenamyloidosis patients 　　LIANGJun-qing1,LUO Dong1,ZHAO Xiao-hong2 　　(1.Department of Dermatology,Xinjiang Uygur Autonomous Region Peoples Hospital,Urumqi 830002,Xinjiang ,China;2.The 94188 Army Hospital) 　　 　　Abstract:Objective To observe the clinical efficacy and safety of0.1% tacrolimus ointment with lattice CO2 laser in treatinglichenamyloidosis patients.Methods32 lichenamyloidosis patients as test group are treatedwith lattice CO2 laser first and then give them 0.1% tacrolimus ointment,once a day,for 4 weeks.31 lichenamyloidosis patients as Control group are treated by only 0.1% tacrolimus ointment,once a day,for 4 weeks,then observed effect.Resluts Test group and control group havestatistically significant difference in efficient and recurrence rate. The treatment group is more effective than the control group, The treatment group showed significantly lower recurrent rate than the control group (P＜0.05).Conclusions 0.1% tacrolimus ointment with lattice CO2 laser therapy lichenamyloidosis patientsshowsafe and effective, the recurrence rate is relatively low, the patients compliance isrelative high. 　　Key words:0.1% tacrolimus ointment;lattice CO2 laser;lichen amyloidosis原发性皮肤淀粉样变病（primary cutaneous amyloidosis）是指淀粉样蛋白沉积在既往正常的皮肤内，而无其他器官受累的一种疾病，临床可分为结节型、斑疹型和苔癣样淀粉变[1]。苔藓样淀粉样变（lichenamyloidosis）是以出现发作性瘙痒的苔藓样丘疹为特征。目前对于原发性皮肤淀粉样变病的治疗通常不满意，尚无特效的治疗方法。近年来研究表明CO2点阵激光能选择性作用于病变皮肤，广泛应用于皮肤科的治疗，具有高效而安全，患者依从性高的特点。2009 年1月～2013年1月，笔者科室应用0.1%他克莫司软膏联合CO2点阵激光治疗苔癣样皮肤淀粉样