参附注射液对老年全麻患者苏醒的影响.docVIP

参附注射液对老年全麻患者苏醒的影响 　　摘 要：目的：观察参附注射液对用于老年全麻患者苏醒期的有效性和安全性。方法 ：将入组的老年全麻患者80例，随机分成S组（40例）和N组（40例）。S组术毕时给予参附注射液1ml/kg5分钟内缓慢静推完毕，而N组给予等量的生理盐水5分钟内缓慢静推完毕。记录术毕时（T1）、给予干预药物后5分钟（T2）、拔除气管导管即刻（T3）、拔除气管导管后10分钟（T4）患者的收缩压、舒张压、心率及ST段情况；记录给药至患者自主呼吸恢复时间、拔管时间及离开手术室时间；用药后30分钟，根据患者的睁眼、语言回答、运动反应对全身麻醉苏醒的认识恢复情况进行GCS积分评分。结果： 两组患者术毕时（T1）血压无明显差异（P0.01），而在（T2、T3 、T4）时血压均有上升，但无明显差异（P0.01）；两组患者心率在T1时无明显统计学差异，在（T2、T3 、T4）时心率均有上升，但无明显差异（P0.01）；在（T1）时，两组患者的ST段无明显差异（P0.01），而在（T2）时，S组的ST段有回升，与N组相比，有明显差异（P0.01）；在自主呼吸恢复时间、拔管时间及离开手术室时间S组均短于N组（P0.01），且GCS评分S组高于N组（P0.01）。结论： 参附注射液用于老年全麻患者苏醒期，能够缩短苏醒时间，提高苏醒质量，且对老年患者苏醒期的血流动力学影响小，能更好地促进老年全麻患者的苏醒。 　　关键词：参附注射液；老年；全麻；苏醒 　　Abstract：Objective to observe the efficacy and safety of Shenfu injection for elderly general anesthesia patients during the waking periods. Methods eighty aged patients with general anesthesia were randomly divided into group S （n=40） and group N （n=40）. When the operation is completed，the samples in group S can be injected with Shenfu injection according to 1ml/kg in 5 minutes . Meanwhile，the group N can be injected the same amount of saline within 5 minutes. We could record the systolic blood pressure， diastolic blood pressure， heart rate and ST segment of patients in different points such as ，the end of operation（T1）， 5 minutes after giving drug intervention （T2）， the moment of removal of tracheal catheter （T3）， 10 minutes after removing tracheal tube （T4）. Record the time from the injection to the recovery of spontaneous breath， the time of extubation and the time of leaving the operating room. We could evaluate the GCS in line with the comprehensive Indicators of patients at 30 minutes after injection. Results in T1， the blood pressure between two groups patients are not significantly difference（P 0.01）. in T2， T3 and T4， blood pressures of all are increased， but no significant difference exists between the two group（P 0.01）. in T1， the heart rate between two groups patients are not significantly difference（P 0.01）. in T2， T3 and T4，