晚期结直肠癌化疗后癌胚抗原及糖类抗原19―9下降率与总生存期的相关性.docVIP

晚期结直肠癌化疗后癌胚抗原及糖类抗原19―9下降率与总生存期的相关性 　　doi：10.3969/j.issn.1007-614x.2014.16.28 　　摘 要 目的：探讨晚期结直肠癌（CRC）血清癌胚抗原（CEA）、糖类抗原19-9（CA19-9）水平与总生存期相关性。方法：收治晚期CRC患者78例，回顾性分析患者临床特征、血清CEA及CA19-9水平变化及总生存期。应用单因素和多因素分析临床特征与生存相关性。结果：单因素分析提示原发肿瘤切除术（P=0.034）、单器官转移（P=0.044）、化疗后血清CEA下降≥25%（P=0.000）及血清CA19-9下降≥50%（P=0.001）患者生存期明显延长。多因素分析提示多器官转移（P=0.043）、化疗后血清CEA下降25%（P=0.023）及CA19-9下降50%（P=0.027）是生存独立预测因子。结论：化疗后血清CEA及CA19-9下降率可预测晚期CRC患者生存。 　　关键词 结直肠癌 癌胚抗原 糖类抗原19-9 生存 　　The correlation of serum carcinoembryonic antigen and carbohydrate antigen 19-9 level of advanced colorectal cancer with the overall survival 　　Chen Xinggui ，Zhou Hechao，Yang Zhicheng，Yi Xiaoqiong，Zhang Ying 　　Cancer Center，Affiliated Hospital of Guangdong Medical College，Zhanjiang City，Guangdong 524001 　　Abstract Objective：To investigate the correlation of serum carcinoembryonic antigen（CEA） and carbohydrate antigen 19-9（CA19-9） level of advanced colorectal cancer（CRC） with overall survival.Methods：78 cases with advanced CRC were selected.The clinical characteristics，changes of serum CEA and CA19-9 levels and overall survival were retrospectively analyzed.We analyzed the relationship between clinical features and survival by univariate and multivariate.Results：Single factor analysis showed that the survival time of patients with resection of the primary tumor（P=0.034），single organ metastasis（P=0.044），serum CEA decline≥25% after chemotherapy（P=0.000） and serum CA19-9 decline≥50%（P=0.001） was significantly longer.Multivariate analysis showed that multiple organ metastasis（P=0.043），serum CEA decline25% after chemotherapy（P=0.023） and CA19-9 decline50%（P=0.027） were survival independent prognostic factors.Conclusion：Rate of decline of carcinoembryonic antigen and carbohydrate antigen 19-9 after chemotherapy can predict survival in patients with advanced colorectal cancer. 　　Key words Colorectal cancer；Carcinoembryonic antigen；Carbohydrate antigen 19-9；survival 　　晚期结直肠癌（colorectal cancer，CRC）无法行根治性切除术，预后差。如何分辨出预后不良患者