病理生理学13课件.pptVIP

3.致心肌心律失常 Na+-Ca2+ 交换 Ca2+入致一 过性内向 离子流 迟后除极 4.促进氧自由基生成 Ca2+ (+) Ca2+依赖性蛋白酶(XD→XO) 5.肌原纤维过度收缩 胞内Ca2+ 收缩 再灌注 H+ H+对心肌收缩的抑制 Ischemia-reperfusion injury of myocardium induced by Ca2+ overload. Ca2+ overload Activation of Ca2+ dependent pathways Ca2+accumulation of mitochondrion Activation of myocardial excitation-contraction coupling Activation of protease Activation of phospholipase A2 Dysfunction of mitochondrion Continual contraction of myocardium OFR Degradation of membrane phospholipid Myocardium necrosis thromboxane Thrombosis Energy creation↓ Energy exhaustion↑ Injury of membrane arach