2011-Antioxidant,cytotoxic,antitumor,andprotectiveDNA=FX=抗氧化细胞毒等.doc

窗体顶端 窗体底端 Pharmacognosy Res. 2011 Jul-Sep; 3(3): 160–165. doi:? 10.4103/0974-8490.85000 PMCID: PMC3193615 Copyright : ? Pharmacognosy Research Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp Seif-Eldin N. Ayyad, Saleh T. Ezmirly, Salim A. Basaif, Walied M. Alarif,1 Adel F. Badria,2 and Farid A. Badria3 Department of Chemistry, Faculty of Science, King Abdul Aziz University, P. O. 80203, Jeddah 21589, KSA 1Department of Marine Chemsitry, Faculty of Marine Sciences, King Abdulaziz University, Jeddah 21589, P. O. 80207, KSA 2Tissue Engineering Lab., Faculty of Dentistry, Alexandria University, Alexandria, Egypt 3Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt Address for correspondence: Dr. Seif-Eldin N Ayyad, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. E-mail: snayyad2@ Received February 1, 2011; Revised April 6, 2011; Accepted September 16, 2011. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Macroalgae can be viewed as a potential antioxidant and anti-inflammatory sources owing to their capability of producing compounds for its protection from environmental factors such as heat, pollution, stress, oxygen concentration, and UV radiations. Objective: To isolate major compounds which are mainly responsible for the pharmacological activity of brown alga under investigation, Sargassum sp. Materials and Methods: Algal material was air dried, extracted with a mixture of organic solvents, and fractionated with different adsorbents. The structures of obtained pure compounds were elucidated with different spectroscopic techniques, and two pure materials were tested for protection of DNA from damage, an