Growth Hormone Silver Falls School District生长激素银落学区.pptVIP

Growth Hormone (GH) Holly Farris What Is It? 191-amino acid, single chained polypeptide Synthesized, stored, and secreted by?somatotrophic cells Anterior Pituitary gland Function Increased height in childhood and adolescents –most known effect Increases mineralization of bones Muscle mass Stimulates growth of internal organs- excluding the brain Immune system Positive or Negative? Negative High blood levels of IGF-I leads to decreased secretion of GH IGF-1 directly suppresses the somatotrophic cells Hyper Gigantism- excessive growth, usually in childhood Most common Pituitary Tumor