离子交换树脂在药物制剂中的应用.PDFVIP

54 2007 7 (2007)04–0216–05 Chinese Journal of Pharmaceutics Vol. 5 No.4 Jul. 2007 p.216 1 110016 2 201203 10 21 1935 D’Alelio R94 A Adams Holmas [1] 1945 [2] 20 70 FDA RohmHass 23 1 [3] 2007 01 15 (1979 ), , , E-mail liuhongfei1979@; 1958 Tel.024E-mail ppwwss@163.com , [4-5] , Tel 217 1) 2) 3) 4) 5) 6) “” 2 [6] 1 —SO3H 120 100 2 —N(CH3)3OH 60 RohmHass 2 RohmHass pH 0~14 AmeberliteIR 120 pH 0~14 Amberlite IRA 400 80 [7] “” 2.1 1956 Raghunathan 218 5 pH “” Pennwalt [8-11] impregnating agent PEG4000 Pennkinetic? [12-15] Amberlite GC 120 Delsym Amberlite IRP 69 [16-17] [18-2