Perceptual Consequences of Disrupted Auditory Nerve Activity听觉神经活动中断的知觉后果.pptVIP

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Perceptual Consequences of Disrupted Auditory Nerve Activity听觉神经活动中断的知觉后果.ppt

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Perceptual Consequences of Disrupted Auditory Nerve Activity听觉神经活动中断的知觉后果

Perceptual Consequences of Disrupted Auditory Nerve Activity FAN-GANG ZENG, YING-YEE KONG, HENRY J MICHALEWSKI, AND ARNOLD STARR Journal of Neurophysiology Vol:93;2005 Presenters: Anusha Ramesh Bijan Saikia Guides: Mr. Animesh Barman Mr. Ajith Kumar. Introduction Perception is a delicate chain of events that includes conversion of a sensory stimulus into electrical signals and processing and interpretation of the electrical signal in the CNS. Electric stimulation of the auditory nerve via a cochlear implant in persons with hearing impairment results in fundamental changes in the brain affecting behaviors ranging from basic psychophysics to language development. Clinically, these studies often lead to better diagnosis and management of a particular disease. Theoretically, these studies shed light on the relative contribution of different neural codes to perception at a mechanism level. The clinical diagnosis of AN has been typically characterized by the presence of otoacoustic emission and/or cochlear microphonics and the concurrent absence of the averaged auditory brainstem responses. Despite absent auditory brainstem responses, it is evident that sound information must have been transmitted because individuals with AN can hear sound, have normal brain imaging, and identifiable although usually delayed cortical potentials (Rance et al. 2002; Starr et al. 2003; Zeng et al. 1999). The distorted auditory nerve activity has been suggested in the form of : desynchronized or reduced discharge in the auditory nerve. Desynchronized neural discharge can occur due to demyelination and ion-channel dysfunction in the auditory nerve and/or dysfunctional synaptic transmission between the inner hair cells and the auditory nerve. Loss of the neural input to the brain can occur due to inner hair cell loss and/or auditory nerve loss. Although the term AN has been widely accepted clinically as a diagnosis, alternative terms such as auditory dys-synchrony have