Photodynamic Therapy of Cancer The Design and光动力疗法治疗癌症的设计和.pptVIP

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Photodynamic Therapy of Cancer The Design and光动力疗法治疗癌症的设计和.ppt

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Photodynamic Therapy of Cancer The Design and光动力疗法治疗癌症的设计和

Photodynamic Therapy of Cancer: The Design and Characterization of Photosensitizing Agents Angela Dann Monday, October 9, 2006 History Introduction Process of Photodynamic therapy (PDT) PDT to treat cancer Photosensitizing Agents Requirements Advancements Trials using PDT on tumor cells Conclusions Future applications History Light used as therapeutic agent for 3000+ years Egyptian, Indian, and Chinese civilizations Psoriasis, rickets, vitiligo, skin cancer Photodynamic Therapy (PDT) developed within the last century History History Niels Finsen (late 19th century) Red light to prevent formation and discharge of small pox postules UV light from the sun to treat cutaneous tuberculosis Nobel Prize 1903 Oscar Rabb (100+ years ago) Acridine in combination with certain wavelengths of light Lethal to infusoria History Herman Von Tappeiner, A. Jesionek Defined photodynamic action Topically applied eosin and white light W. Hausmann 1st studies with haematoporphyrin and light Killed paramecium and red blood cells Friedrich Meyer-Betz (1913) 1st to treat humans with porphyrins Haematoporphyrin applied to skin, causing swelling/pain with light exposure History Samuel Schwartz (1960’s) Developed haematoporphyrin derivative (HpD) Haematoporphyrin treated with acetic and sulfuric acids, neutralized with sodium acetate Lipson, E.J. Baldes HpD localization in tumor cells, fluorescence I. Diamond (1972) Use PDT to treat cancer History Thomas Dougherty (1975) HpD and red light Eradicated mammary tumor growth in mice J.F. Kelly (1976) 1st human trials using HpD Bladder cancer Canada (1999) 1st PDT drug approved Introduction:Process of Photodynamic therapy Two individually non-toxic components brought together to cause harmful effects on cells and tissues Photosensitizing agent Light of specific wavelength Introduction:Reaction Mechanisms Type 1: Direct reaction with substrate (cell membrane or molecule) Transfer of H atom to form radicals Radicals react with O2 to form oxygenat