儿童性早熟诊断中性激素检测的临床应用分析.docVIP

儿童性早熟诊断中性激素检测的临床应用分析 　　【摘要】 目的：探讨性激素检测对于儿童性早熟诊断的应用效果及其作用原理，深入探究其临床应用价值，最终为儿童性早熟的诊治提供更多可靠性依据。方法：选取2013年3月-2015年3月本院收治的58例女性儿童特发性中枢性性早熟患儿作为研究组，随机选取门诊有性早熟体征的同龄同阶段部分性中枢性性早熟女性儿童37例作为对照组，采取回顾性的研究方法分析两组儿童的性激素水平，并进行科学对比与统计，最后得出结果和结论。结果：（1）两组患儿的促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇（E2）、垂体催乳素（PRL）四项指标比较差异均有统计学意义（P0.05）；（2）两组患儿的FSH峰值、LH峰值、LH峰值/FSH峰值比较差异均有统计学意义（P0.05）；（3）两组患儿在子宫容积、卵巢容积及卵泡直径大于4 mm数上比较差异均有统计学意义（P0.05），且研究组各项指标呈明显增大趋势。结论：在儿童性早熟的诊断中应用六项性激素检测配合激素指标超出阈值情况可有效判定儿童性早熟基本情况，可为临床治疗及疗效评估提供重要依据，具有积极的社会意义及临床应用推广价值。 　　【关键词】 儿童； 性早熟； 诊断； 性激素； 应用效果 　　Clinical Application Analysis of Early Diagnosis of Sex Hormone Detection in Children with Precocious Puberty/CHENG Shuang-xi，GUO Tao-bo，CHEN Ai-xin.//Medical Innovation of China，2016，13（06）：116-119 　　【Abstract】 Objective：To explore the effect and mechanism of sex hormone detection in the diagnosis of precocious puberty in children， and explore its clinical application value， and provide more reliable basis for the diagnosis and treatment of precocious puberty. Method： 58 female children with idiopathic central precocious puberty in our hospital from March 2013 to March 2015 were selected as the study group， and 37 cases of central female children were randomly selected as the control group， the sex hormone levels of the two groups of children were analyzed， made a comparison and statistics， and finally got the results and conclusions.Result：（1）Promote follicle stimulating element （FSH）， and luteinizing hormone generating element （LH）， estradiol （E2）， prolactin （PRL） four index comparison showed significant differences in the two groups， the differences were statistically significant（P4 mm） of the two groups were significantly different（P0.05）， the indicators of the study group showed a significantly increased trend.Conclusion：In the diagnosis of precocious puberty in childrens application of six sex hormone test combined with hormone index is beyond the threshold which can effectively determine the children precocious puberty basic si