反复呼吸道感染患儿血清25羟基维生素D3、免疫球蛋白的变化.docVIP

反复呼吸道感染患儿血清25羟基维生素D3、免疫球蛋白的变化 　　【摘要】 目的：探讨反复呼吸道感染患儿血清25羟基维生素D3[25-hydroxyvitamin D3，25-（OH）D3]、免疫球蛋白的变化。方法：选择200例诊断为反复肺部感染的患儿作为病例组，采用随机数字表法均分为常规组与观察组，常规组给予常规抗炎治疗，观察组在常规治疗基础上补充维生素D，于治疗前、治疗后3个月检测25-（OH）D3、免疫球蛋白水平；选择100例健康儿童作为健康组，检测25-（OH）D3、 　　免疫球蛋白水平作为参照值，分析其与肺部感染的相关性。结果：病例组治疗前25-（OH）D3、IgG、IgA均明显低于健康组，差异均有统计学意义（P0.05）；治疗后25-（OH）D3、IgG、IgA均较治疗前明显升高，差异均有统计学意义（P0.05）；但25-（OH）D3、IgA均低于健康组，差异均有统计学意义（P0.05）。治疗后常规组与观察组患儿25-（OH）D3、IgG、IgA均较治疗前升高，差异均有统计学意义（P0.05）；且治疗后观察组25-（OH）D3、IgG、IgA则较常规组升高更明显，差异均有统计学意义（P0.05）。随访1年观察组复发例数、需住院治疗人次及症状持续平均天数均明显低于常规组，差异均有统计学意义（P0.05）。结论：反复呼吸道感染患儿多存在血清25-（OH）D3、IgG、IgA水平低下，在积极抗感染治疗基础上，给予患儿补充维生素D可更好地提高机体免疫功能。 　　【关键词】 反复呼吸道感染； 血清25羟基维生素D3； 免疫球蛋白 　　【Abstract】 Objective：To analyze the changes of serum 25-hydroxyvitamin D3[25-（OH）D3] and immune globulin in children with recurrent respiratory infection.Method：A total of 200 children with recurrent respiratory infection were included as the case group.All patients were divided into the conventional group and the observation group.Patients in the conventional group were given conventional treatment，and patients in the observation group were given vitamin D supplement.25-（OH）D3 and immune globulin were detected before and 3 months after treatment.100 healthy children were included as the health group.25-（OH）D3 and immune globulin were also detected as a reference value.Result：25-（OH）D3，IgG，IgA in the case group were lower than those of the health group，the differences were statistically significant（P0.05）.25-（OH）D3，IgG，IgA in the case group 3 months after treatment were higher than those of before treatment，the differences were statistically significant（P0.05）.25-（OH）D3，IgA in the case group 3 months after treatment were still lower than those of the health group，the difference were statistically significant（P0.05）.25-（OH）D3，IgG，IgA 3 months after treatment in the conventional treatment group and the observation group were higher than those of before treatment，the differences were statisticall