原创力文档Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine- 2,5-dicarboxamide Derivatives as MMP 13 Inhibitors.pdf
- 1、本文档共4页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
查看更多
Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine- 2,5-dicarboxamide Derivatives as MMP 13 Inhibitors.pdf
Chem．Res．Chin．Univ．2013，29(1)，67—70 doi：10．1007／s40242-012-213l-2
Design，SynthesisandEvaluationof6-Oxo一1，6-dihydropyrimidine-
2,5-dicarboxamideDerivativesasMM P13Inhibitors
LUHai．bin，WANGShi．han，LIQing．minandWANGYong．sheng，
，．CollegeofPharmacy,JilinUniversity,Changchun130021．尸R．China,
2．ChangchunUniversityofChineseMedicine，Changchun130021， R．China
Abstract Wedesignedandsynthsizedaseriesofnovel6-oxo-1，6-dihydropyrimidine一2，5-dicarboxamidederivatives
andevaluatedtheirinhibitioneffectsonMMP3，MMP12na dMMP 13．Thepharmacologicalresultsshow thatthey
havepotentandhighlyselectiveactivityofinhibitingMMP13．
Keywords Matrixmetal1oproteinase13(MMPl3)；Matrixmetalloproteinase(MMP)；Inhibition
1 lntrOductiOn inhibitorsofMⅣIP13．
The synthetic M ⅣlPs inhibitors with low moleculra
Matrix metalloproteinases(MMPs) are a family of weightsareusedinthetreatmentofthesediseases．Theseinhi-
Zn．dependentendOpeptidasesinvolvedinthedegradationna d
bitorsgenerallyincludeazincbindinggroup(ZBG)，capableto
repairofthemajorcomponentsoftheextracellularmatrixof efficientlychelatethecatalyticzincion．boundtoasubstrate-
connective tissuest1,2J
． These enzymesare involved in many
likefragmentdesignedtofittheS1primaryspecificitysubsite
physiologicalprocesses such as ovulation，embryogenesis， nadadjacentsubsitesL“J．Hydroxamateisconsideredtobethe
angiogenesis．cellulra differentiation，nadwound healingt3,4J．
mostef
文档评论（0）