transitionmetalcomplexesofanovelquinoxalinebased.docVIP

Transition metal complexes of a novel Quinoxaline based tridentate ONO donor ligand: Synthesis, spectral characterization, thermal, in vitro pharmacological and molecular modeling studies Chellaian Justin Dhanaraj*, Jijo Johnson Department of Chemistry, University College of Engineering, Nagercoil (Anna University Constituent College), Konam, Nagercoil – 629 004, Tamil Nadu, India Supplementary data Experimental Materials The chemicals used were of AnalaR grade except o-phenylenediamine, which was purified by recrystallization from hot methanol. Bromine, calcium carbonate, metal(II) acetates and solvents were bought from Merck. Sodium pyruvate, glacial acetic acid and 2-amino-5-chlorobenzophenone were bought from SRL PVT. Ltd., India. The chemicals were used as received without any further purification. Instrumentation Elemental analysis of ligand and its metal complexes were carried out using Perkin-Elmer elemental analyzer. Molar conductance of the complexes was measured using Systronic, MK-509 digital conductivity meter. IR spectra were recorded using Brucker ALPHA-D spectrophotometer by KBr pellet method from 4000-100 cm-1. 1H NMR spectra of ligand and its Zn(II) complex were recorded with Brucker 500 MHz spectrometer using CDCl3 solvent with TMS as internal standard. 13C NMR spectra of ligand and its Zn(II) complex were recorded with Brucker 400 MHz spectrometer using CDCl3 solvent with TMS as internal standard. DART-MS spectra were recorded on a JEOL-Accu TOF JMS mass spectrometer. Magnetic moments were measured by Guoy method and corrected for diamagnetism of the component using Pascal’s constants. Electronic spectra were recorded on Lasany UV-Visible double beam spectrophotometer (Model No. I-2902) at the wavelength range 190-1100 nm. Electron spin resonance (ESR) spectra of the Cu(II) complex were recorded at 300 and 77 K in DMSO solution using Varian, USA E-112 ESR spectrometer using tetracyanoethylene (TCNE) as g-marker. Thermal analysis was carried