Evidence of contact activation in patients suffering from ST-elevation myocardial infarction.pdfVIP
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Evidence of contact activation in patients suffering from ST-elevation myocardial infarction.pdf
Thrombosis Research 141 (2016) 158–162
Contents lists available at ScienceDirect
Thrombosis Research
journal homepage: /locate/thromres
Full Length Article
Evidence of contact activation in patients suffering from ST-elevation myocardial infarction
Kjeld Christensen a,c, Huda Kozarcanin b,c, Kristina N. Ekdahl b,c, Bo Nilsson b,c,?
a Department of Cardiology, ?rebro University Hospital, Sweden b Department of Immunology, Genetics and Pathology, Rudbeck Laboratory C5:3, Uppsala University, S-751 85, Sweden c Linn?us Center for Biomaterials Chemistry, Linn?us University, SE-391 82 Kalmar, Sweden
article info
Article history: Received 29 September 2015 Received in revised form 16 February 2016 Accepted 16 March 2016 Available online 18 March 2016
Keywords: Contact system FXII AT C1INH STEMI
abstract
Introduction: Factor (F) XIIa is an attractive target for anticoagulation in arterial thrombosis. The aim of this study is to investigate the degree of involvement of the contact system in cardiac infarctions. Methods and patients: 165 patients suffering from ST-elevation myocardial infarction (STEMI) and 100 healthy controls were included in the study. Samples were drawn at admission before percutaneous intervention (PCI), 1–3 days post-percutaneous intervention (PCI) and, in one-third of the patients, 3 months after PCI. In order to investigate the degree of Factor XII (FXII) activation, changes in FXIIa/AT and FXIIa/C1INH complex levels were quanti?ed by ELISA. Results: FXIIa/AT levels at admission (0.89 ± 0.50; p b 0.01) were signi?cantly higher than those in normal individuals (0.39 ± 0.28), but the levels after 1–3 days (0.33 ± 0.33; p b 0.05) were essentially normalized. In contrast, the FXII/C1INH levels at admission (1.40 ± 0.72; p b 0.001) and after 1–3 days (0.83 ± 0.59; p b 0.001) were both signi?cantly higher than those in normal individuals (0.40 ± 0.30). FXIIa/AT and FXIIa/C1INH complexes at admission (p b 0.001; p b 0.001) and after 1–3 days (p b 0.02; p b 0
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