Voltage-gated sodium channels viewed through a structural biology lens.pdfVIP

Available online at ScienceDirect Voltage-gated sodium channels viewed through a structural biology lens Thomas Clairfeuille1, Hui Xu1, Christopher M Koth and Jian Payandeh Voltage-gated sodium (Nav) channels initiate and propagate action potentials in excitable cells, and are frequently dysregulated or mutated in human disease. Despite decades of intense physiological and biophysical research, eukaryotic Nav channels have so far eluded high-resolution structure determination because of their biochemical complexity. Recently, simpler bacterial voltage-gated sodium (BacNav) channels have provi