MTT体外药敏试验指导下的乳癌预见性化疗.pdfVIP

f ；． I 中华肿庙杂志1997年3月第19卷第2期 MTT体外药敏试验指导下的 7 7- 乳癌预见性化疗 徐建明 宋三泰 汤仲明 江泽飞 周 莉 刘晓晴 李彦博 杨奕静 _’～ - _ — —～ _ 摘要 目的 探讨3(4，5)一双甲基I2一噻唑一(2，5)一二苯基溴化四氮唑蓝(MTT)体外药敏试验指 导临床乳癌化疗的价值。方法 156倒晚期乳癌病人中，83倒在化疗前接受了MTT体外药敏试验 其中MTT敏感组73倒，根据药敏结果指导化疗：MTT耐药组10例、对照组73例则凭经验化疗。 结果 MTT敏感组有效率为76．7 (56／73)，MTT耐药组和对照组分别为0(0／10)及43．8 (32／73)．差异有显著意义。敏感组与对照组在不同的治疗阶段、大部分病灶及化疗方案的小组比较 中，差异也均有显著意义。敏感组病人再次复发转移率、死亡率显著减少．但再度复发病人的中位缓解 期及中位生存期尚无显著变化。车研究体外药敏和体内疗效的总符合率为79．5 [(56+l0)／833。 结论 MTT体外药敏试验指导乳癌化疗是可行的，疗效也是满意的。 主题词兰 ! ，堑! ．竺三二 皇 鸦铋i 淀 Predictive chemotherapy of breast cancer directed by MTT assay in vitro Xu Jianming，Song San tai，Tang Zhongming，et a1．Beijing North Taiping Road Hospital Cancer Center，BeOing 100039 Al~iract Objective The predictive value of in vitro MTT assay for chemotherapy to breast cancer patients was studied．Methods Ofthe l 56 advanced breast cancer patients．83 had hadMTT assay before chemotherapy．According to the result of the MTT assayt 73 patients in MTT sensitive group received chemotherapy．The other 10 patients in MTT resistant group and 73 patients in the control group were given chemotherapy according to clinician’experience．Results The response rate in MTT sensitive group was 76．7 (56／73)．There was statistically significant difference as compared with 0(o／1 0)in the resistant group and 43．8 (32／73)jn the control group．Between MTT sensitive group and control group，similar results were obtained at different therapeutic pha— ses．in the subgroups of most lesions and chemotherapeutic schemes．Both the relapse rate and Tnor_ tal[ty rate were reduced remarkably in the MTT sensitive group But there was no difference in the median remission and survival of relapsed patients in the two groups．Between in vitro and in vivo t the overal