脉血康胶囊联合羟基脲片治疗真性红细胞增多症临床研究.docVIP

脉血康胶囊联合羟基脲片治疗真性红细胞增多症临床研究 　　摘要：目的 观察脉血康胶囊联合羟基脲片治疗真性红细胞增多症（PV）的临床疗效，及不良反应。方法 随机将52例PV患者分为试验组、对照组各26例。对照组给予西药羟基脲片治疗；试验组在对照组的基础上加用脉血康胶囊。观察两组患者治疗前后临床完全缓解率、中医证候积分、外周血象的变化及不良反应。结果 试验组临床完全缓解80.76%，对照组临床完全缓解率为46.15%。两组治疗前后中医症候积分差值，试验组为（8.85±1.18）；对照组为（5.02±0.99）。两组治疗后外周血，红细胞、血红蛋白及血小板均降低。试验组血小板降低较对照组明显。患者治疗过程中无明显用药后不良反应发生。结论 脉血康胶囊联合羟基脲片治疗PV 疗效较单用羟基脲片显著，可明显改善PV患者中医症候及外周血象，并可减少羟基脲片的不良反应，提高PV 患者的生活质量。 　　关键词：真性红细胞增多症；脉血康胶囊；羟基脲片；中西医结合疗法 　　Abstract：Objective To observe the clinical effect of Vein blood kang capsule in the treat of Polycythemia Vera（PV） and to compare with the group which use western medicine ，hydroxyurea only. Methods The treatment group of 19 cases use vein blood kang capsule and hydroxyurea.The control group of 19 cases use hydroxyurea only. Observe the clinical complete remission rate，total efficiency of TCM syndromes and TCM syndrome scores.Results The complete remission rate in treatment group was 80.76% ，and in control group was 46.15 %. Two groups in total efficiency of TCM syndromes have significant difference compared.The reduce of platelet have difference，the treatment group has much more difference from the control group.And in the research，there are no untoward effects. Conclusion Vein blood kang capsule with hydroxyurea could improve PV patients the blood routines ， reduce adverse reactions of hydroxyurea and improve their quality of life than hydroxyurea only ，and it can also reduce the untoward effects of hydroxyurea.It can improve the quality of PV life . 　　Key words：Polycythemia vera；Vein blood kang capsule；Hydroxyurea；Combination of Chinese traditional and Western medicine therapy 　　真性?t细胞增多症（Polycythemia vera，PV） 简称真红，是一种克隆性骨髓增生性的疾病，以红细胞异常增多为主，并伴有白细胞、血小板增多[1]。临床以皮肤紫红、血栓、肝脾肿大、头晕、头痛、高血压、手脚麻木等症状为主[2]。目前治疗方法有：静脉放血、化疗药物、中医中药治疗。药物使用，特别是化疗药物之中常用的有：羟基脲片、干扰素a、三尖杉酯碱、烷化剂，临床证实有效，但维持用药易复发，并出现血栓、栓塞、出血等并发症，PV患者生活质量难以提升，甚至会导致死亡[3]。真性红细胞增多症就中医的角度，属于血证、?Y积、血积、血实、眩晕、积证等范畴[4]。按照中医的辩证论治原则，在常规西药治疗的同时，配合使用具有活血化瘀中成药脉血康胶囊，可使PV患者血瘀症状得到明显改善。现对52例我院住院及门诊长期随访的PV患者进