幽门螺旋杆菌感染及中心性浆液脉络膜视网膜病变关系Meta分析.pdfVIP

META．ANALYSIS 0F ASSoCIATION BET、ⅦEN HELICOBACTER PYLoIU AND CENTRALSERoUS CHoIUoRETINOPATHY ABSTRACT OBJECTIF：Recent evidences indicate Helicobacter pylori饵．pylori) may plays a role in Central Serous Chorioretinopathy(csc)．The author systematically investigated the association between H．pylori and CSC． METHOUDS：A meta-analysis of 5 published case-control studies， which examined the relation between H．pylori and CSC，was carded out． RESULTS：贮=4．49，P=0．29，12=20％，fixed effects model Was applied to process data．The pooled OR of the association between H． pylori and CSC was 2．15(95％CI，1．40-3．32)，p=O．0005．The analytical result of sensitivity proved that the result of Meta-analysis was coherent． After omitting studies that contributed significantly to the heterogeneity, there is no great difference of the pooled OR．The publication bias has been well controlled． CONCLUSIONS：Individuals with H．pylori have an increased risk of developing CSC． Key words：Helicobacter pylori；Central Serous Choriomtinopathy； 3 risk factor；Meta-analysis 4 重庆医科大学硕士研究生学位论文 英文缩写 ALK5 CI CNV CSC FFA H．pylori HSP HTFs IKK LDL MMC NF．1cB Nfs OR PDT I心E siRNA SPf撇 VEGF 13C．UBT 英汉缩略语名词对照 英文全称 Activin receptor-like kinase 5 Confidence interval Choroidal newvascularization Central Serous Chorioretinopathy Fundus fluorescein angiography Helicobacter pylori heat shock proteins Human Tenon’s fibroblasts 11cB kinase 功w densi哆lipoprotem Mitomycin C nuclear factor kappa B Fail．safe number Odd radio Photodynamic therapy Retinal pigment epithelium Small interferingRNA secreted protein acidic and rich in cysteine vascular endothelial growth factor 1 3C．I lrea Breath Test 中文全称 活化素受体样激酶5 可信区间 脉络膜新生血管 中心性浆液性脉络膜 视网膜病变 眼底荧光素血管造影 幽门螺旋杆菌 热休克蛋白 人Tenon’s囊成纤维细 胞 Ird3激酶 低密度脂蛋白 丝裂霉素C 核因子．r,B 失安全系数 优势比 光动力治疗 视网膜色素上皮层 小干扰核糖核酸 富含半胱氨酸的酸性 分泌蛋白 血管内皮生长因子 1 3C．尿素呼气试验 重庆医科大学硕士研究生学位论文 幽门螺旋杆菌感染与中心性浆液性脉络膜视网膜病变 关系的Meta分析 前言 中心性浆液性脉络膜视网膜病变(Central Serous Choriorctinopathy，CSC)是 具有自愈倾向的疾病，大部分病人可以自发缓解恢复视力，但部分患者病程慢性 发展或反复发作可导致视网膜色素上皮层(RPE)失代偿和严