模拟移动床分离EMD+53986对映体的模拟与分析.pdfVIP

模拟移动床分离EMD 53986 对映体的模拟与分析 郑 丽，马正飞 （南京工业大学化学化工学院 材料化学工程国家重点实验室，江苏 南京 210009） 摘要：过程模拟采用了考虑因素全面的综合速率模型，其中流动相模型为轴向扩散活塞流，颗粒 相为fick 定律描述的扩散方程，液相和固相之间的吸附平衡采用改进的Langmuir 吸附等温线。 对流动相和颗粒相分别采用有限元Galerkin 法和正交配置法，沿空间方向离散化后的常微分方程 组运用MATLAB 的ODE 求解器求解，验证了模型和选取方法对模拟移动床吸附分离过程计算的 可靠性。模拟了EMD 53986 对映体的模拟移动床分离过程，与移动床模型的模拟结果比较，表明 孔内过程对模拟移动床模拟的重要性，分析了周期性稳态和暂态过程。 关键词：模拟移动床；色谱；综合速率模型 中图分类号：TQ 028.8 文献标示码：A 文章编号： Simulation and Analysis of EMD 53986 Enantiomers Resolution by Simulated Moving Bed ZHENG Li ，MA Zhengfei (State Key Laboratory of Materials-Oriented Chemical Engineering，College of Chemistry and Chemical Engineering ，Nanjing University of Technology ，Nanjing 210009 ，China) Abstract: Simulated moving bed (SMB) is a continuous chromatographic process to separate mixtures. Economical advantages of SMB have firmly established in recent years as the state of the art technology for complex separation tasks in the areas of pharmaceuticals, fine chemicals and biotechnology. Due to the complexity of the SMB process, simulations are necessary at many stages in the development of a specific application. In the paper, a general rate model is presented for the simulation of a simulated moving bed. Axial dispersion flow for the bulk fluid phase and diffusion equation described by fick law for the particle phase are included, and the equilibrium concentration is given by a modified competitive Langmuir isotherm. The model which used Galerkin and orthogonal collocation methods was discretized into a series of ordinary differential equations (ODEs). The ODEs were then solved by ODE solver provided by MATLAB. The results show that these numerical simulations are credibility. Simulation results are com