N-杂环卡宾钯催化剂研究报告.docxVIP

2010年，Michael G. Gardiner和他的同事合成了新型的氮杂环卡宾化合物，A colorless solution of 1 over anhydrous Na2CO3 in dryMeOH was heated at 508C for two hours to give a redsolution, from which red crystals of 2 were obtained in 84%yield after filtration and concentration (Scheme 1).[8] Complex 2 has high stability as a solid (more than one year) and inMeOH and THF (several months). The complex is tolerant tomoisture, but reacts quickly with atmospheric oxygen insolution and the solid state.Peter D. W. Boyd, Alison J. Edwards, Michael G. Gardiner, Angew. Chem. Int. Ed. 2010, 49, 6315 –6318.2008年，Takeshi Makino和他的同事得到了具有二齿氮杂环配体的钯配合物，The bidentate NHC-palladium complexes 4a–e were prepared by the reaction of 1-(4-iodoaryl)-3-aryl-4,5-dihydroimidazolinium salt (1)[16] and xanthenediboronic acid (2)[17] in the presence of Pd(PPh3)4 and Ag2O followed bypalladation[18] (Scheme 1). The bis(imidazolidene) derivative 6 was also synthesized in a similar way(Scheme 2).Takeshi Makino, HyumaMasu, KosukeKatagiri, Ryu Yamasaki, Isao Azumaya,and Shinichi Saito，Eur. J. Inorg. Chem. 2008, 4861–4865.There are many examples of monodentate NHCs, but only afew examples of alkane-bridged chelating biscarbeneligands.Chelatedcarbenes are expected to be more stable since onepossible decomposition pathway, reductive elimination of thecarbene, should be slower for this conformationally restrictedcase. A chelating coordination is one way to obtain highly stablecatalysts capable of tolerating harsher reaction conditions thantraditional phosphine catalysts. Sebastian Ahrens和他的同事化合物长链烷烃桥联配体的钯配合物，Sebastian Ahrens, Alexander Zeller, Maria Taige, and Thomas StrassnerOrganometallics, Vol. 25, No. 22, 2006N-Heterocyclic carbenes (NHCs), first prepared independently by Wanzlick and Schnherr[1] and fele[2] in 1968,attracted little interest from the chemical community until1991, when Arduengo et al. revealed the first stable, crystalline NHC (1, IAd).[3] The potential of this class of compoundsto serve as spectator ligands in