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A Novel pH Sensitive N-Succinyl Chitosan Alginate Hydrogel.pdf

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A Novel pH Sensitive N-Succinyl Chitosan Alginate Hydrogel

BIOPHARMACEUTICS DRUG DISPOSITION Biopharm. Drug Dispos. 29: 173–184 (2008) Published online in Wiley InterScience () DOI: 10.1002/bdd.590 A Novel pH Sensitive N-Succinyl Chitosan/Alginate Hydrogel Bead for Nifedipine Delivery Ya-Ni Daia,b, Ping Lia,*, Jun-Ping Zhangc, Ai-Qin Wangc and Qin Weia a The Second Hospital of Lanzhou University, Lanzhou, 730030, China b Pharmacy College of Lanzhou University, Lanzhou, 73000, China c Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China ABSTRACT: A novel N-succinyl chitosan(Suc-Chi)/alginate hydrogel bead was prepared by the ionic gelation method for the controlled delivery of nifedipine. The structure and surface morphology of the hydrogel were characterized by FTIR and SEM, respectively. Factors influencing the swelling ability of the hydrogel bead were also investigated, such as the ratio of Suc-Chi and alginate (X1), the weight ratio of drug to polymer (X2), the volume ratio of alginate/Suc-Chi to CaCl2 (X3), crosslinking time (X4), CaCl2 concentration (X5). In addition, the delivery behavior of nifedipine from the hydrogel bead was studied. The amount of nifedipine released from the hydrogel bead at pH 1.5 was relatively low (11.6%), while this value approached 76% at pH 7.4. The results clearly suggested that the Suc-Chi/alginate hydrogel bead may be a potential polymeric carrier for drug delivery in the intestinal tract. The release of nifedipine from the hydrogel bead at various pH values was analysed by a semi-empirical equation and it was found that the drug release mechanisms were either ‘anomalous transport’ or ‘case-II transport’. Copyright # 2008 John Wiley Sons, Ltd. Key words: N-succinyl-chitosan; pH sensitivity; hydrogel; nifedipine; delivery Introduction Hydrogels, chemically or physically crosslinked three-dimensional networks composed of hydro- philic polymers, can absorb and retain large amounts of aqueous fluids, and the absorbed water is hardly removable even unde