Functional connectivity mapping of the human precuneus by resting state fMRI.pdf

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Functional connectivity mapping of the human precuneus by resting state fMRI.pdf

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Functional connectivity mapping of the human precuneus by resting state fMRI

NeuroImage 59 (2012) 3548–3562 Contents lists available at SciVerse ScienceDirect NeuroImage j ourna l homepage: www.e lsev ie r .com/ locate /yn imgFunctional connectivity mapping of the human precuneus by resting state fMRI Sheng Zhang a,?, Chiang-shan R. Li a,b,c a Department of Psychiatry, Yale University, New Haven, CT 06519, United States b Department of Neurobiology, Yale University, New Haven, CT 06520, United States c Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, United States? Corresponding author at: Connecticut Mental Healt New Haven CT 06519, United States. Fax: +1 203 974 7 E-mail address: sheng.zhang@ (S. Zhang). 1053-8119/$ – see front matter ? 2011 Elsevier Inc. All doi:10.1016/j.neuroimage.2011.11.023a b s t r a c ta r t i c l e i n f oArticle history: Received 12 May 2011 Revised 2 November 2011 Accepted 4 November 2011 Available online 12 November 2011 Keywords: Functional connectivity fMRI Resting state Precuneus Default networkPrecuneus responds to a wide range of cognitive processes. Here, we examined how the patterns of resting state connectivity may define functional subregions in the precuneus. Using a K-means algorithm to cluster the whole-brain “correlograms” of the precuneus in 225 adult individuals, we corroborated the dorsal- anterior, dorsal-posterior, and ventral subregions, each involved in spatially guided behaviors, mental imagery, and episodic memory as well as self-related processing, with the ventral precuneus being part of the default mode network, as described extensively in earlierwork. Furthermore,we showed that the lateral/medial volumes of dorsal anterior and dorsal posterior precuneus are each connectedwith areas ofmotor execution/attention and motor/visual imagery, respectively. Compared to the ventral precuneus, the dorsal precuneus showed greater connectivity with occipital and posterior parietal cortices, but less connectivity with the medial superior frontal and orbitofrontal gyri, an