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The large-scale organization of metabolic networks
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The large-scale organization of metabolic networks
H. Jeong
1
, B. Tombor
2
, R. Albert
1
, Z. N. Oltvai
2
and A.-L. Barabási
1
1
Department of Physics, University of Notre Dame, Notre Dame, IN 46556, and
2
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611
In a cell or microorganism the processes that generate mass, energy, information transfer, and
cell fate specification are seamlessly integrated through a complex network of various cellular
constituents and reactions 1. However, despite the key role these networks play in sustaining
various cellular functions, their large-scale structure is essentially unknown. Here we present
the first systematic comparative mathematical analysis of the metabolic networks of 43
organisms representing all three domains of life. We show that, despite significant variances in
their individual constituents and pathways, these metabolic networks display the same
topologic scaling properties demonstrating striking similarities to the inherent organization of
complex non-biological systems 2. This suggests that the metabolic organization is not only
identical for all living organisms, but complies with the design principles of robust and error-
tolerant scale-free networks 2-5, and may represent a common blueprint for the large-scale
organization of interactions among all cellular constituents.
An important goal in biology is to uncover the fundamental design principles that provide the
common underlying structure and function in all cells and microorganisms 6-13. For example, it is
increasingly appreciated that the robustness of various cellular processes is rooted in the dynamic
interactions among its many constituents 14-16, such as proteins, DNA, RNA, and small molecules.
Recent scientific developments improve our ability to identify the design principles that integrate these
interactions into a complex system. Large-scale sequ
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