原创力文档BAB2007-Bacillus minimum genome factory-effective utilization of microbial genome information.pdf
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BAB2007-Bacillus minimum genome factory-effective utilization of microbial genome information
Biotechnol. Appl. Biochem. (2007) 46, 169–178 (Printed in Great Britain) doi:10.1042/B169
MINIREVIEW
Bacillus minimum genome factory: effective utilization of
microbial genome information
Katsutoshi Ara*1, Katsuya Ozaki*, Kouji Nakamura?, Kunio Yamane?, Junichi Sekiguchi?
and Naotake Ogasawara§
*Biological Science Laboratories, Kao Co., Ltd., 2606 Akabane, Ichikaimachi, Haga, Tochigi 321-3497, Japan, ?Graduate School
of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki 305-8572, Japan, ?Faculty of
Textile Science and Technology, University of Shinshu, 3-15-1 Tokida, Ueda, Nagano 386-8567, Japan, and §Graduate School
of Information Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan
In 1997, the complete genomic DNA sequence of
Bacillus subtilis (4.2 Mbp) was determined and 4100
genes were identified [Kunst, Ogasawara, Moszer,
Albertini, Alloni, Azevedo, Bertero, Bessieres, Bolotin,
Borchert, S. et al. (1997) Nature 90, 249–256]. In
addition, B. subtilis, which shows an excellent ability
to secrete proteins (enzymes) and antibiotics in large
quantities outside the cell, plays an important role in
industrial and medical fields. It is necessary to clarify
the genes involved in the production of compounds by
understanding the network of these 4100 genes and the
proceeding analysis of genes of unknown functions. In
promoting such a study, it is expected that the regul-
atory system of B. subtilis can be simplified by the
creation of a Bacillus strain with a reduced genome by
discriminating genes unnecessary for the production of
proteins from essential genes, and deleting as many
of these unnecessary genes as possible, which may help
to understand this complex network of genes. We have
previously distinguished essential and non-essential
genes by evaluating the growth and enzyme-producing
properties of strains of B. subtilis in which about 3000
genes (except 271 essential gene
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