Knowledge Integration for Bio-Threat Response.pdf

p. 1 Knowledge Integration for Bio-Threat Response 2/7/05 Knowledge Integration for Bio-Threat Response A White Paper September, 2005 Editors: Karin Verspoor, Cliff Joslyn1, John Ambrosiano (Los Alamos National Laboratory), and Lynette Hirschman (MITRE) Contributors: Alex B?cker (Sandia National Laboratories and Caltech), Olivier Bodenreider (NLM), Peter Karp (SRI), Henry Kelly (Federation of American Scientists), Stephanie Loranger (Federation of American Scientists), Mark Musen (Stanford U.), Ram Sriram (NIST), Chris Wroe (U. Manchester) Introduction......................................................................................................................... 2 The Need: Bio-Threat Response......................................................................................... 3 Current State of the Art....................................................................................................... 6 Database Integration ....................................................................................................... 6 Knowledge Systems in Biological Network Analysis .................................................... 7 Biomedical Ontologies.................................................................................................... 9 Ontological Technologies ............................................................................................. 11 Text and Natural Language Processing ........................................................................ 12 Technology Gaps .............................................................................................................. 14 References......................................................................................................................... 17 Abstract Bio-threats require rapid analysis and response to prevent widespread consequences to the population. The inability to easily link and exploit biological knowledge for bo