Matrix metalloproteinases and cancer - roles in threat and therapy (MINI-REVIEW).pdf

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Matrix metalloproteinases and cancer - roles in threat and therapy (MINI-REVIEW).pdf

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Matrix metalloproteinases and cancer - roles in threat and therapy (MINI-REVIEW)

Asian Pacific Journal of Cancer Prevention, Vol 15, 2014 1085 DOI:/10.7314/APJCP.20085 Matrix Metalloproteinases and Cancer - Roles in Threat and Therapy Asian Pac J Cancer Prev, 15 (3), 1085-1091 Introduction Cancer is one of the leading causes of mortality and morbidity worldwide (Jemal et al., 2004) and in addition to genetic features, environmental factors are also important in modulating the individual susceptibility to it (Cao and Li, 2006). Carcinogenesis of head and neck is a multistep process (Chaudhary et al., 2010) and the molecular mechanism of complex interaction between the tumour cells and tumour microenvironment play an important role in this process (Gialeli et al., 2011). Matrix metalloproteinases (MMPs) have the ability to regulate the tumour microenvironment and their expression and activation is increased in almost all human cancers compared to normal tissue (Egeblad and Werb, 2002). MMPs are a family of structurally related zinc dependent endopeptidases collectively capable of degrading almost all components of extracellular matrix (Vihinen and Kahari, 2002). MMPs are important not only in normal, physiological and biological processes such as embryogenesis, normal tissue remodelling, wound healing and angiogenesis but also in diseases such as arthritis, cancer tissue ulceration (Sekhon, 2010). Structure and Classification Currently 24 different types of MMPs have been 1Department of Oral and Maxillofacial Pathology, Kalka Dental College, Meerut, 2Department of Oral and Maxillofacial Pathology, Goverment Dental College, Nagpur, 3GMC, Akola Maharashtra, India *For correspondence: drlalita9@ Abstract Matrix metalloproteinases (MMPs) are a family of zinc dependent extracellular matrix (ECM) remodelling endopeptidases having the ability to degrade almost all components of extracellular matrix and implicated in various physiological as well as pathological processes. Carcinogenesis is a multistage process in which altera