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biopharmaceutics
New words
? bioavailability
? systemic: referring to the whole body
? system
the body as a whole
arrangement of certain parts of the body so
that the work together
central nervous system urinary system
? plasma:
? capillary: tiny blood vessels
? endothelium: epithelium,
mesothelium
? intravenous intramuscular
? venous: referring to the veins
? arterial: referring to the artery
New words
capillary electrophoresis
New words
? prodrug: compounds that must undergo
biotransformation (metabolism) before
exhibiting its pharmacological (therapeutic)
effect.
? portal: opening which allows blood vessel to
pass into the organ
? aqueous : non-aqueous
Review
? Absorption: getting into the bloodstream.
? Distribution:. Moving from the bloodstream into
tissues and fluids of the body.
? Metabolism: Physical and chemical alterations
that a substance undergoes in the body.
? Excretion: Eliminating waste products of a drug
metabolism from the body.
drugs at
sites of
administration
(extravascular)
A
B
S
O
R
P
T
I
O
N
bound
drug
unbound
drug
Blood plasma
distribution
distribution
Drugs at sites of action
clinical effect
Unchanged
Drug excreted
metabolites
excreted
E
L
I
M
I
N
A
T
I
O
N
Drugs in tissues (including blood cells)
and other fluids of distribution
(lymph, interstitial fluids)
intravenous injection
bioavailability
? Read the first paragraph, answer questions:
? What does the pharmacological response of a
drug depend on?
? In clinical practice, what is regarded as an
index of drug concentration at sites of action
of a particular drug?
bioavailability
? significance of biopharmaceutics
? Pharmacologic response is dependent, in
large measure, on the concentration of
drug achieved at the site of action.
bioavailability
? Paragraph Two tells you the factors that
may influence the concentration of drug in
blood plasma.
drugs at
sites of
administrat
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