Downregulated gene expression of TGF-bs in diabetic oral wound healing.pdf

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Downregulated gene expression of TGF-bs in diabetic oral wound healing.pdf

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Downregulated gene expression of TGF-bs in diabetic oral wound healing

at SciVerse ScienceDirect Journal of Cranio-Maxillo-Facial Surgery 41 (2013) e42ee48Contents lists availableJournal of Cranio-Maxillo-Facial Surgery journal homepage: Downregulated gene expression of TGF-bs in diabetic oral wound healing Seiichi Yamano a,*, Winston P. Kuo b,c, Cortino Sukotjo d aDepartment of Prosthodontics, New York University College of Dentistry, 345 East 24th Street, 4W, New York, NY 10010, USA b Laboratory for Innovative and Translational Technologies, Harvard Medical School, Boston, MA, USA cDepartment of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA dDepartment of Restorative Dentistry, University of Illinois at Chicago, College of Dentistry, Chicago, IL, USAa r t i c l e i n f o Article history: Paper received 1 September 2011 Accepted 8 August 2012 Keywords: Molecular analysis Gene expressions Oral wound healing Diabetes TGF-b* Corresponding author. Tel.: t1 212 998 9714; fax E-mail address: sy23@ (S. Yamano). 1010-5182/$ e see front matter 2012 European Ass /10.1016/j.jcms.2012.08.001a b s t r a c t Background: Healing of tooth extraction sockets in poorly controlled diabetic patients is often delayed and accompanied by severe infection. The exact cellular and molecular mechanisms underlying the pathogenesis of this complication are still not fully understood. Objectives: The purpose of this study was to investigate molecular changes associated with delayed oral wound healing in diabetes. Materials and methods: Six to eight weeks old male type 2 diabetes and age matched control inbred mice were used and maxillary molar tooth extractions were performed. At 4 and 7 days after tooth extraction, the edentulous mucosa of the mice were harvested, and analyzed for histology and gene expression of key wound healing factors. Results: In the diabetic model, histological analysis showed that epithelial tissue migration for wound closure was delayed after tooth extraction compared to the control. Quantitative rea