赣州市人民医院泌尿外科邓小林：维生素D与男性不育症的相关要点.ppt

一、VD来源及代谢 二、VD功能 （五）VD调节精子Ca2+浓度 （五）VD调节精子Ca2+浓度 调节网络 （七）与睾酮的季节性 （十）维生素D治疗少弱精子症 （二）调节精子蛋白磷酸化 酪氨酸磷酸化 苏氨酸磷酸化 J Anat. 2008 Nov;213(5):555-64.Human sperm anatomy: ultrastructural localization of 1alpha,25-dihydroxyvitamin D receptor and its possible role in the human male gamete （三）VD与精子存活 J Anat. 2008 Nov;213(5):555-64.Human sperm anatomy: ultrastructural localization of 1alpha,25-dihydroxyvitamin D receptor and its possible role in the human male gamete （四）VD与精液参数 Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human reproduction, 2011. 26(6): p. 1307-1317 （四）VD与精液参数 精子活力 前向运动精子比率 正常精子形态比例 Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human reproduction, 2011. 26(6): p. 1307-1317 （五）VD调节精子Ca2+浓度 Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human reproduction, 2011. 26(6): p. 1307-1317 Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human reproduction, 2011. 26(6): p. 1307-1317 （六）调节顶体反应 Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human reproduction, 2011. 26(6): p. 1307-1317 25(OH)VD 睾酮 游离睾酮指数 Clin Endocrinol (Oxf). 2010 Aug;73(2):243-8.Association of vitamin D status with serum androgen levels in men （七）与睾酮的季节性 Clin Endocrinol (Oxf). 2010 Aug;73(2):243-8.Association of vitamin D status with serum androgen levels in men （八）流行病学 Fertil Steril. 2011 Mar 1;95(3):1000-4.Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. （九）VD和精液常规参数 邓小林，郭树林，宋乐明，2014.12《中国男科学》25-羟化维生素D和精液常规参数的相关性分析 邓小林，郭树林，宋乐明。2014年12期《中华男科学杂志》维生素D治疗特发性少弱精子症的有效性与安全性研究 ×106 每次射精前向活动精子数、前向运动精子比例 (3个月后治疗组P0.05) 团结奋进，德高技精 2014年总结及2015年计划 Schematic overview of the proposed cellul