MulticenterAIDSCohortStudy-IAS-USA.pptVIP

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MulticenterAIDSCohortStudy-IAS-USA

Issues in the Aging HIV-Infected Population;HIV and Aging;Similarities between HIV Infection and Aging;Age Issues in Effect of HIV/HAART;;Resting Energy Expenditure and Covariates in HIV+ and HIV- Subjects;Changes in Immune Activation Markers after HAART in the MACS;Risk of Incident Diabetes Mellitus in the Multicenter AIDS Cohort Study (1999-2003);Homeostatic Systems Disrupted in HIV Infection;Frailty: A Brief Overview;Fried, L. P. et al. J Gerontol A Biol Sci Med Sci 2009 64A:1049-1057;Theoretical Pathogenesis of Frailty [1];Frailty: How Is It Recognized?;Frailty in HIV Infection: Why Is It Important?;Multicenter AIDS Cohort Study (MACS);Frailty in the MACS (1994-2005);Studies of a Frailty-Related Phenotype (FRP) in the Multicenter AIDS Cohort Study (MACS);Frailty-Related Phenotype (FRP) and Duration of HIV Infection (Pre-HAART Era);CD4 T-cell count (cells/μl);Prognostic Effect of FRP on HAART Response (AIDS-free at HAART Initiation);Impact of FRP in the 3 years before HAART initiation on subsequent clinical AIDS or death among 596 men enrolled in the MACS, using multivariate Cox models ;HIV-1 infection associated with 10-year earlier occurrence of FRP [1] Risk of FRP increased nonlinearly with decreasing CD4 cell count, especially ~400/mm3 [2] After adjusting for age and CD4 cell count, FRP prevalence decreased after the introduction of HAART [2] Older age, lower educational level, and clinical AIDS were independently associated with FRP among HIV+ men [1] Proportion and number of visits with FRP in 3 yrs before starting HAART independently predicted risk of AIDS or death after HAART, even in those with HIV suppression [3] [1] Desquilbet L et al, J. Gerontol A Biol. Sci. Med. Sci. 62:1279-1286, 2007. [2] Desquilbet L et al, J. Acquir. Immune Def. Syndr. 50:299-306, 2009. [3] Desquilbet L et al, J. Gerontol A Biol. Sci. Med. Sci. 66A:1030-1038, 2011. ;Prevalence of Frailty Phenotype by Age and HIV Status (MACS, 2009-10);Prevalence Ratio of Frailty Phenot

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