结构生物学sturcture biology explore-38.pdfVIP

464 Designing supramolecular protein assemblies Todd O Yeates* and Jennifer E Padilla Many natural proteins self-assemble, either to fulfill their D- and L-amino acids) that self-assembled to form filaments. biological function or as part of a pathogenic process. Several variations on this theme have been explored as Biological assembly phenomena such as amyloidogenesis, well [15–18,19?,20]. Here, we review recent work on linear domain swapping and symmetric oligomerization are inspiring assemblies built from proteins or polypeptides containing new strategies for designi