A Mutant with a Defect in Telomere Elongation.pdfVIP

Cell, Vol. 57, 633-643, May 19, 1989, Copyright ? 1989 by Cell Press A Mutant with a Defect in Telomere Elongation Leads to Senescence in Yeast Victoria Lundblad* and Jack W. Szostak Department of Genetics Harvard Medical School and Department of Molecular Biology Massachusetts General Hospital Boston, Massachusetts 02114 Summary We describe a general assay designed to detect mu- tants of yeast that are defect ive for any of several aspects of telomere function. Using this assay, we have isolated a mutant that displays a progress ive de- crease in telomere length as well as an