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Adipose-derived stem cells promote peripheral nerve repair
Adipose-derived stem cells promote peripheral nerve
repair
Gui-Bo Liu1,2, Yong-Xia Cheng3, Yu-Kuan Feng2, Chao-Jian Pang1, Qi Li1, Ying Wang1,2, Hua Jia1,
Xiao-Jie Tong1
A b s t r a c t
Introduction: Recent evidence suggests that the implantation of bone marrow-
derived mesenchymal stem cells improves peripheral nerve regeneration. In this
study we aimed to investigate whether adipose-derived stem cells (ADSCs) can
be used for peripheral nerve repair.
Material and methods: In a rat model, nerve regeneration was evaluated across
a 15 mm lesion in the sciatic nerve by using an acellular nerve injected with
allogenic ADSCs. The walking behaviour of rats was measured by footprint
analysis, and electrophysiological analysis and histological examination were
performed to evaluate the efficacy of nerve regeneration.
Results: Cultured ADSCs became morphologically homogeneous with a bipolar,
spindle-like shape after ex vivo expansion. Implantation of ADSCs into the rat
models led to (i) improved walking behaviour as measured by footprint analysis,
(ii) increased conservation of muscle-mass ratio of gastrocnemius and soleus
muscles, (iii) increased nerve conduction velocity, and (iv) increased number of
myelinated fibres within the graft.
Conclusions: Adipose-derived stem cells could promote peripheral nerve repair
in a rat model. Although the detailed mechanism by which ADSCs promote
peripheral nerve regeneration is being investigated in our lab, our results suggest
that ADSCs transplantation represents a powerful therapeutic approach for
peripheral nerve injury.
Key words: adipose-derived stem cells, peripheral nerve repair, cell transplantation,
sciatic nerve.
Introduction
Mesenchymal stem cells (MSCs) are an attractive cell source for the
regeneration of nerve tissue due to their self-renewal ability, high growth
rate and multi-potent differentiation properties [1]. In particular, the
implantation of bone marrow-derived mesenchymal stem cells (BMMSCs)
has been shown to
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