Book reading of Miller.pptVIP

* * * * * * * * * * * (芳香羥) (延長鹼基可延長效果) * * * * * * * * * * * * * * * * * n. * * * * * * * * Pharmacology --GABAA receptor of CNS: (1) enhancement of the synaptic actions of inhibitory neurotransmitters (2) blockade of the synaptic actions of excitatory neurotransmitters --GABA為擁有五個鍵結位子的氯離子通道. 只有GABAA 與barbiturates有關. 增加氯流入使細胞hyperpolarization. --也可抑制glutamate and acetylcholine等興奮性物質 Barbiturates Effects on Cerebral Metabolism --dose-related depression ?slowing of the EEG, reduction in the rate of ATP consumption , protection from incomplete cerebral ischemia -