Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal.pdfVIP

Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks* Received for publication, April 19, 2006, and in revised form, August 10, 2006 Published, JBC Papers in Press, August 10, 2006, DOI 10.1074/jbc.M603747200 Haruyuki Takemura1, V. Ashutosh Rao1, Olivier Sordet1, Takahisa Furuta, Ze-Hong Miao, LingHua Meng, Hongliang Zhang, and Yves Pommier2 From the Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, National Institutes of Health, Department of Health and Hum