wnt signaling controls the fate of mesenchymal stem cells.pptxVIP

Wnt signaling controls the fate of mesenchymal stem cells GENE 2008.12.3 1. Wnt signaling pathways 2.Wnt signaling and MSCs 3.conclusion 1. Wnt signaling pathways (1)Canonical Wnt signaling pathway (2)non-canonical Wnt signaling pathway (3)Regulation of Wnt signaling Wnt proteins are cysteine-rich secreted glyco-lipoproteins that regulate development,cell proliferation and motility, cell fate determination, and the generation of cell polarity. 1. Wnt signaling pathways (Wnt proteins are assembled and secreted)  (Activated canonical Wnt signaling: Activated non-canonical Wnt signaling; inactivated Wnt signaling.) Wnt 1, 2, 3 and 3a,8 and 8b are regarded as the canonical Wnts , and Wnt4, 5a, 5b, 6, 7a and 11 as the non-canonical. Regulation of Wnt signaling Antagonizing Wnt singaling at the receptor level β-catenin`s degradation and accumulation The activity of Wnt is regulated by extracellular factors The complex regulation of Wnt singaling (Antagonizing Wnt singaling at the receptor level) (β-catenin`s degradation accumulation) The activity of Wnt is regulated by extracellular factors , specifically heparan sulfate proteoglycans. Therefore , the choice of which pathway will transduce which Wnt signal appears to be subject to cellular and/or functional context 2.Wnt signaling and MSCs The self-renewal of MSCs Osteogenesis Chondrogenesis Adipogenesis Myogengsis Cell dinsity and lineage commitment Cross-talk between Wnt and other growth factor signaling pathways 3.conclusion Various studies have suggested that the effects of Wnt signaling are context-dependent.