曲男哥论文慢性肾脏病患者虚弱现状的系统评价定稿.doc

慢性肾脏病患者虚弱现状的系统评价 曲男1 宋洁1 张成成1 邓志强2 孟焕1 （1.山东中医药大学护理学院，济南250355；2.山东省千佛山医院血液净化室，济南250014） 摘 要 目的 了解慢性肾脏病（chronic kidney disease，CKD）患者的虚弱现状及影响因素。方法 检索中国知网、维普、万方、Pubmed、CINAHL、Embase数据库，深入阅读文献，采用单个率的meta分析评价文献。结果 纳入9篇文献，CKD患者虚弱的发生率在2.8%~73%之间，透析CKD患者的虚弱发生率为44%。虚弱与CKD密切相关，虚弱程度也与肾脏损伤程度有关，同时，性别、年龄、CKD分期、eGFR、肥胖、高血压、透析、心理状况等均被确立为虚弱的危险因素。结论 CKD患者更易虚弱，导致虚弱的原因多种多样，今后有待加强我国CKD患者虚弱现状及综合护理干预的研究。 关键词 虚弱；慢性肾脏病；系统评价 A systematic review of frailty state in chronic kidney disease patients Qu Nan，Song Jie，Zhang Cheng Cheng，Deng Zhi Qiang，Meng Huan. (Nursing College，Shandong University of Traditional Chinese Medicine，Jinan 250355) Corresponding author: Song Jie，E-mail: sjbir Abstract Objective Through retrieving and reading existing literatures, the state and influence factors in chronic kidney disease patients were came to understand. Method CNKI, VIP, Wan Fang PubMed, CINAHL and Embase databases were retrieved and these Literatures were read carefully, using a single rate of meta analysis to evaluate these literatures. Result Nine literatures were included. The prevalence of frailty in CKD patients was 2.8%~73%, and the prevalence of frailty in dialysis patients were 44%.Frailty was closely related to CKD. The degree of frailty is not only related to the extent of kidney damage but also to gender, age, CKD stage, eGFR, obesity, hypertension, dialysis, mental state, etc which were established as risk factors of frailty in CKD patients. Conclusion CKD patients were more likely to be frailty, a variety of reasons led to be frailty. More studies about frailty states and comprehensive nursing intervention in CKD patients should be paid more attention in our country in the future. 【Key Words】 frailty; chronic kidney disease; systematic review 依据美国肾脏病基金会（National Kidney Foundation, NKF）制定的CKD定义、分期及临床实践指南进行流行病学研究发现，我国普通人群中CKD的患病率约为9%～13%[1]，CKD已成为威胁人们健康的公共卫生问题，会引起心血管疾病、贫血、肾性骨营养不良等并发症，严重威胁患者生命健康，同时给患者家庭带来巨大的经济和照料负担。虚弱是一种常见的多维综合征，包括身体和认知障碍、生理储备下降和应激反应较差等[2]，虚弱的危险因素众多，包括