近红外光谱对布洛芬空间分布的研究.doc

Study of spatial distribution for the active ingredient in ibuprofen Tablet based on near-infrared micro-imaging technology Dong Wang
, Yun Sheng ning , Jin Li cao Yue He ,Sheng Feng ye
, Shun Geng Min
, College of science, China Agricultural University, Beijing 100193, china,yunnan Tobacco company Dali branch, Dali 671000 ,china, Beijing Research Center information Technology in Agricultural, Beijing, 100097,china , Received 15 March 2011 Available online 3 September 2011 Abstract The NIR micro-images of ibuprofen tablets were collected in this research.Compare correlation imaging and Principal Component analysis(PCA) with histogram were applied to acquire the spatial distribution of ibuprofen granule.The result indicated that a similar distribution trend can be acquired by both of the two methods mentioned above;the information of PC2 results from ibuprofen mainly since the correlation coefficient between PC2 loading vector and the NIR spectrum of ibuprofen is 0.9930. The result of PCA indicated that the information of PC2 results from ibuprofen mainly for both the low and the high content of ibuprofen in the tablets.The correlation coefficient between the data of the two PC2 loading vectors of the low and the high content of ibuprofen in the tablets is 0.9998, which indicates that the result of PCA is stable and reliable. keywords:Near-infrared micro-imaging;Compare correlation imaging;Principal component analysis;Ibuprofen;Spatial distribution Tablet Plays an important role in Pharmaceuticals. Although the traditional analytical method [1]can determine the acive ingredient in tablets precisely, the procedure of this work is full of complicated Preprocessing. It is time consuming with high cost for chemical reagents and high demand for operators. With the development of chemometrics and computer technology in recent years, NIR spectroscopy analysis, With the advantages of free of preprocessing, non-destructive analysis, multi-i